Ciprofloxacin-loaded dissolving polymeric microneedles as a potential therapeutic for the treatment of S. aureus skin infections

• Sharif Abdelghany,
• Walhan Alshaer,
• Yazan Al Thaher,
• Maram Al Fawares,
• Amal G. Al-Bakri,
• Saja Zuriekat and
• Randa SH. Mansour

Beilstein J. Nanotechnol. 2022, 13, 517–527, doi:10.3762/bjnano.13.43

• results suggest that CIP_MN1 can be a potential delivery system for the treatment of S. aureus skin infections. Keywords: dissolving microneedles; microneedles; polyvinyl alcohol (PVA); polyvinylpyrrolidone (PVP); skin infection; Introduction Topical and transdermal drug delivery is a major route for

• human skin. Also, the dissolution of these microneedles in excised human skin and the concentration of ciprofloxacin in each layer of the excised human skin was studied. We designed an in vitro model of skin infection to compare the microneedles with free gel and, consequently, the antimicrobial

• . aureus. The results suggest that PVA/PVP microneedles were able to withstand the insertion force and to fully penetrate Parafilm and agarose gel. Moreover, the superiority of this delivery system over conventional administration of free gel in excised human skin and in an in vitro skin infection model